One year of funding to support new components and activities of the MRCE and Trans-Center projects beneficial to the national Biodefense Network.Funds can be applied to objectives such as: enhancing the capabilities of the Centers and the Biodefense Network, encouraging inter-Center activities, and providing additional research, development, and training opportunities. Since one of the goals for all RCEs is to develop vaccines, therapeutics, and diagnostics that are targeted to the Category A-C agents, projects directly related to achieving this goal will be given high priority. Projects exhibiting real novelty and genuine innovation will also be given extra consideration.