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Animal Models

Using biomarkers to stage disease progression in a lethal mousepox model treated with CMX001 Parker S, Schriewer J, Oberle C, Robertson A, Lanier R, Painter G, Buller RM. Antivir Ther: 2008;13(7):863-73

Experimental infection of an African dormouse (Graphiurus kelleni) with monkeypox virus Schultz DA, Sagartz JE, Huso DL, Buller RM. Virology: 2008 Oct 31

Differential susceptibility of SD and CD rats to a novel rat theilovirus Drake MT, Riley LK, Livingston RS. Comp Med: 2008 Oct;58(5):458-64

An immunosuppressed Syrian golden hamster model for SARS-CoV infection Schaecher SR, Stabenow J, Oberle C, Schriewer J, Buller RM, Sagartz JE, Pekosz A. Virology: 2008 Aug 27

Murine norovirus: a model system to study norovirus biology and pathogenesis Wobus CE, Thackray LB, Virgin HW 4th. J Virol: 2006;80(11):5104-5112

Sampling methodologies and dosage assessment techniques for submicrometre and ultrafine virus aerosol particles Hogan CJ Jr, Kettleson EM, Lee MH, Ramaswami B, Angenent LT, Biswas P. J Appl Microbiol: 2005;99:1422-1434

Pathophysiological manifestations in mice exposed to anthrax lethal toxin Culley NC, Pinson DM, Chakrabarty A, Mayo MS, Levine SM. Infect Immun: 2005;73(10):7006-7010

Anthrax

Targeting of the BclA and BclB proteins to the Bacillus anthracis spore surface Thompson BM, Stewart GC. Mol Microbiol: 2008 Oct;70(2):421-34

Targeting of the BclA and BclB proteins to the Bacillus anthracis spore surface Thompson BM, Stewart GC. Mol Microbiol: 2008 Oct;70(2):421-34

Effect of 2-Fluorohistidine Labeling of the Anthrax Protective Antigen on Stability, Pore Formation, and Translocation Wimalasena DS, Cramer JC, Janowiak BE, Juris SJ, Melnyk RA, Anderson DE, Kirk KL, Collier RJ, Bann JG. Biochemistry: 2007 Dec 25;46(51):14928-36

Effect of 2-Fluorohistidine Labeling of the Anthrax Protective Antigen on Stability, Pore Formation, and Translocation Wimalasena DS, Cramer JC, Janowiak BE, Juris SJ, Melnyk RA, Anderson DE, Kirk KL, Collier RJ, Bann JG. Biochemistry: 2007 Dec 25;46(51):14928-36

Cloning, purification and crystallization of Bacillus anthracis class C acid phosphatase Felts RL, Reilly TJ, Calcutt MJ, Tanner JJ. Acta Crystallograph Sect F Struct Biol Cryst Commun: 2006;62:705-708

Cloning, purification and crystallization of Bacillus anthracis class C acid phosphatase Felts RL, Reilly TJ, Calcutt MJ, Tanner JJ. Acta Crystallograph Sect F Struct Biol Cryst Commun: 2006;62:705-708

Pathophysiological manifestations in mice exposed to anthrax lethal toxin Culley NC, Pinson DM, Chakrabarty A, Mayo MS, Levine SM. Infect Immun: 2005;73(10):7006-7010

Pathophysiological manifestations in mice exposed to anthrax lethal toxin Culley NC, Pinson DM, Chakrabarty A, Mayo MS, Levine SM. Infect Immun: 2005;73(10):7006-7010

Antibody

Human monoclonal antibodies against West Nile virus induced by natural infection neutralize at a postattachment step Vogt MR, Moesker B, Goudsmit J, Jongeneelen M, Austin SK, Oliphant T, Nelson S, Pierson TC, Wilschut J, Throsby M, Diamond MS. J Virol: 2009 Jul;83(13):6494-507

A therapeutic antibody against west nile virus neutralizes infection by blocking fusion within endosomes Thompson BS, Moesker B, Smit JM, Wilschut J, Diamond MS, Fremont DH. PLoS Pathog: 2009 May;5(5):e1000453

The structural immunology of antibody protection against West Nile virus Diamond MS, Pierson TC, Fremont DH. Immunol Rev: 2008 Oct;225:212-25

The structural immunology of antibody protection against West Nile virus Diamond MS, Pierson TC, Fremont DH. Immunol Rev: 2008 Oct;225(1):212-25

Molecular mechanisms of antibody-mediated neutralisation of flavivirus Pierson TC, Diamond MS. Expert Rev Mol Med: 2008 May 12;10:e12

The relative contribution of antibody and CD8+ T cells to vaccine immunity against West Nile encephalitis virus Bimmi Shresthaa, Terry Ngb, Hsien-Jue Chub, Michelle Nolla and Michael S Diamond. Vaccine: 2008 Apr 7;26(16):2020-33

Structure of antibody-neutralized murine norovirus and unexpected Katpally U, Wobus CE, Dryden K, Virgin HW 4th, Smith TJ. J Virol: 2008 Mar;82(5):2079-88

Binding of a neutralizing antibody to dengue virus alters the arrangement of surface glycoproteins Lok SM, Kostyuchenko V, Nybakken GE, Holdaway HA, Battisti AJ, Sukupolvi-Petty S, Sedlak D, Fremont DH, Chipman PR, Roehrig JT, Diamond MS, Kuhn RJ, Rossmann MG. Nat Struct Mol Biol: 2008 Mar;15(3):312-7

The molecular basis of antibody protection against West Nile virus Mehlhop E, Diamond MS. Curr Top Microbiol Immunol: 2008;317:125-53

Complement protein c1q inhibits antibody-dependent enhancement of flavivirus infection in an IgG subclass-specific manner Mehlhop E, Ansarah-Sobrinho C, Johnson S, Engle M, Fremont DH, Pierson TC, Diamond MS. Cell Host Microbe: 2007;2(6):417-26

Type- and Sub-Complex-Specific Neutralizing Antibodies Against Domain III of Dengue Virus Type-2 Envelope Protein Recognize Adjacent Epitopes Sukupolvi-Petty S, Austin SK, Purtha WE, Oliphant T, Nybakken GE, Schlesinger JJ, Roehrig JT, Gromowski GD, Barrett AD, Fremont DH, Diamond MS. J Virol: 2007;81(23):12816-12826

Induction of Epitope-Specific Neutralizing Antibodies against West Nile virus Oliphant T, Nybakken GE, Austin SK, Xu Q, Bramson J, Loeb M, Throsby M, Fremont DH, Pierson TC, Diamond MS. J Virol: 2007;81(21):11828-11839

Antibody recognition of cell surface-associated NS1 triggers Fc-y receptor mediated phagocytosis and clearance of WNV infected cells Kyung Min Chung, Bruce S Thompson, Daved H Fremont, and Michael S Diamond. J Virol: 2007;81(17):9551-9555

The molecular basis of antibody-mediated neutralization of West Nile virus Theodore Oliphant, Michael S Diamond. Expert Opin Biol Ther: 2007;7(6):885-892

Defining limits of humanized neutralizing monoclonal antibody treatment for West Nile virus neurological infection in a hamster model Morrey JD, Siddharthan V, Olsen AL, Wang H, Julaner JG, Hall JO, Li H, Nordstrom JL, Koenig S, Johnson S, Diamond MS. Antimicrob Agents Chemother: 2007;51(7):2396-2402

Antibody recognition and neutralization determinants on domains I and II of West Nile Virus envelope protein Oliphant T, Nybakken GE, Engle M, Xu Q, Nelson CA, Sukupolvi-Petty S, Marri A, Lachmi BE, Olshevsky U, Fremont DH, Pierson TC, Diamond MS. J Virol: 2006;80(24):12149-12159

Antibodies against West Nile Virus nonstructural protein NS1 prevent lethal infection through Fc gamma receptor-dependent and -independent mechanisms Chung KM, Nybakken GE, Thompson BS, Engle MJ, Marri A, Fremont DH, Diamond MS. J Virol: 2006;80(3):1340-1351

Structural basis of West Nile Virus neutralization by a therapeutic antibody Nybakken GE, Oliphant T, Johnson S, Burke S, Diamond MS, Fremont DH. Nature: 2005;437:764-769

Development of a humanized monoclonal antibody with therapeutic potential against West Nile virus Oliphant T, Engle M, Nybakken GE, Doane C, Johnson S, Huang L, Gorlatov S, Mehlhop E, Marri A, Chung KM, Ebel GD, Kramer LD, Fremont DH, Diamond MS. Nat Med: 2005;11(5):522-530

Arbovirus

Tickborne arbovirus surveillance in market livestock, Nairobi, Kenya Sang R, Onyango C, Gachoya J, Mabinda E, Konongoi S, Ofula V, Dunster L, Okoth F, Coldren R, Tesh R, da Rossa AT, Finkbeiner S, Wang D, Crabtree M, Miller B. Emerg Infect Dis: 2006 Jul;12(7):1074-80

Autophagy

Autophagy genes in immunity Virgin HW, Levine B. Nat Immunol: 2009 May;10(5):461-70

Autophagy genes in immunity Virgin HW, Levine B. Nat Immunol: 2009 May;10(5):461-70

A common role for Atg16L1, Atg5 and Atg7 in small intestinal Paneth cells and Crohn disease Cadwell K, Patel KK, Komatsu M, Virgin HW 4th, Stappenbeck TS. Autophagy: 2009 Feb;5(2):250-2

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells Cadwell K, Liu JY, Brown SL, Miyoshi H, Loh J, Lennerz JK, Kishi C, Kc W, Carrero JA, Hunt S, Stone CD, Brunt EM, Xavier RJ, Sleckman BP, Li E, Mizushima N, Stappenbeck TS, Virgin HW 4th. Nature: 2008 Nov 13;456(7219):259-63

The autophagy gene ATG5 plays an essential role in B lymphocyte development Miller BC, Zhao Z, Stephenson LM, Cadwell K, Pua HH, Lee HK, Mizushima NN, Iwasaki A, He YW, Swat W, Virgin HW 4th. Autophagy: 2008 May-Jun;4(3):309-14

Coronavirus Replication Does Not Require the Autophagy Gene ATG5 Zhao Z, Thackray LB, Miller BC, Lynn TM, Becker MM, Ward E, Mizushima NN, Denison MR, Virgin HW 4th. Autophagy: 2007;3(6):581-585

PKR-dependent autophagic degradation of herpes simplex virus type I Talloczy Z, Virgin HW 4th, Levine B. Autophagy: 2006;2(1):24-29

Bacterial Pathogenesis

Golgicide A reveals essential roles for GBF1 in Golgi assembly and function José B Sáenz, William J , Jae Won Chang, Jinmei Li, Badry Bursulaya, Nathanael S Gray & David B Haslam. Nature Chemical Biology 5, 157 - 165 (: 2009)

Phosphonosulfonates are potent, selective inhibitors of dehydrosqualene synthase and staphyloxanthin biosynthesis in Staphylococcus aureus Song Y, Lin FY, Yin F, Hensler M, Rodrígues Poveda CA, Mukkamala D, Cao R, Wang H, Morita CT, González Pacanowska D, Nizet V, Oldfield E. J Med Chem. 2009 Feb 26;52(4):976-88

Quantitative metabolomics reveals an epigenetic blueprint for iron acquisition in uropathogenic Escherichia coli Henderson JP, Crowley JR, Pinkner JS, Walker JN, Tsukayama P, Stamm WE, Hooton TM, Hultgren SJ. PLoS Pathog. 2009 Feb;5(2):e1000305

Targeting of the BclA and BclB proteins to the Bacillus anthracis spore surface Thompson BM, Stewart GC. Mol Microbiol: 2008 Oct;70(2):421-34

Effect of 2-Fluorohistidine Labeling of the Anthrax Protective Antigen on Stability, Pore Formation, and Translocation Wimalasena DS, Cramer JC, Janowiak BE, Juris SJ, Melnyk RA, Anderson DE, Kirk KL, Collier RJ, Bann JG. Biochemistry: 2007 Dec 25;46(51):14928-36

Structure of Recombinant Haemophilus Influenzae e (P4) Acid Phosphatase Reveals a New Member of the Haloacid Dehalogenase Superfamily Richard L Felts, Zhonghui Ou, Thomas J Reilly, and John J Tanner. Biochemistry: 2007;46(39):11110-11119

Structure of Recombinant Haemophilus Influenzae e (P4) Acid Phosphatase Reveals a New Member of the Haloacid Dehalogenase Superfamily Richard L Felts, Zhonghui Ou, Thomas J Reilly, and John J Tanner. Biochemistry: 2007;46(39):11110-11119

Differences in the electrostatic surfaces of the type III secretion needle proteins PrgI, BsaL, and MxiH Yu Wanga, Andrew N Ouellettea, Chet W Egana, Thenmalarchelvi Rathinavelana, Wonpil Ima and Roberto N De Guzman. J Mol Biol: 2007;371(5):1304-1314

Differences in the electrostatic surfaces of the type III secretion needle proteins PrgI, BsaL, and MxiH Yu Wanga, Andrew N Ouellettea, Chet W Egana, Thenmalarchelvi Rathinavelana, Wonpil Ima and Roberto N De Guzman. J Mol Biol: 2007;371(5):1304-1314

Identification and characterization of small molecules that inhibit intracellular toxin transport Jose B Saenz, Teresa A Doggett, David B Haslam. Infect Immun: 2007;75(9):4552-4561

A plasminogen-activating protease specifically controls the development of primary pneumonic plague Lathem WW, Price PA, Miller VL, Goldman WE. Science: 2007;315(5811):509-513

A plasminogen-activating protease specifically controls the development of primary pneumonic plague Lathem WW, Price PA, Miller VL, Goldman WE. Science: 2007;315(5811):509-513

Rationally designed small compounds inhibit pilus biogenesis in uropathogenic bacteria Pinkner JS, Emaut H, Buelens F, Miller e, Aberg V, Pemberton N, Hedenstrom M, Larsson A, Seed P, Waksman G,
Hultgren SJ, Almqvist F. Proc Natl Acad Sci U S A: 2006;103(47):17897-17902

Rationally designed small compounds inhibit pilus biogenesis in uropathogenic bacteria Pinkner JS, Emaut H, Buelens F, Miller e, Aberg V, Pemberton N, Hedenstrom M, Larsson A, Seed P, Waksman G,
Hultgren SJ, Almqvist F. Proc Natl Acad Sci U S A: 2006;103(47):17897-17902

RovA, a global regulator of yersinia pestis, specifically required for bubonic plague Cathelyn JS, Crosby SD, Lathem WW, Goldman WE, Miller VL. Proc Natl Acad Sci U S A: 2006;103(36):13514-13519

RovA, a global regulator of yersinia pestis, specifically required for bubonic plague Cathelyn JS, Crosby SD, Lathem WW, Goldman WE, Miller VL. Proc Natl Acad Sci U S A: 2006;103(36):13514-13519

Cloning, purification and crystallization of Bacillus anthracis class C acid phosphatase Felts RL, Reilly TJ, Calcutt MJ, Tanner JJ. Acta Crystallograph Sect F Struct Biol Cryst Commun: 2006;62:705-708

Cloning, purification and crystallization of Bacillus anthracis class C acid phosphatase Felts RL, Reilly TJ, Calcutt MJ, Tanner JJ. Acta Crystallograph Sect F Struct Biol Cryst Commun: 2006;62:705-708

Crystallization of recombinant Haemophilus influenzae e (P4) acid phosphatase Ou Z, Felts RL, Reilly TJ, Nix JC, Tanner JJ. Acta Crystallograph Sect F Struct Biol Cryst Commun: 2006;62:464-466

Crystallization of recombinant Haemophilus influenzae e (P4) acid phosphatase Ou Z, Felts RL, Reilly TJ, Nix JC, Tanner JJ. Acta Crystallograph Sect F Struct Biol Cryst Commun: 2006;62:464-466

Crystallization of a newly discovered histidine acid phosphatase from Francisella tularensis Felts RL, Reilly TJ, Calcutt MJ, Tanner JJ. Acta Crystallograph Sect F Struct Biol Cryst Commun: 2006;62:32-35

Crystallization of a newly discovered histidine acid phosphatase from Francisella tularensis Felts RL, Reilly TJ, Calcutt MJ, Tanner JJ. Acta Crystallograph Sect F Struct Biol Cryst Commun: 2006;62:32-35

The identification and characterization of two phosphatidylinositol-4,5-bisphosphate 4-phosphatases Ungewickell A, Hugge C, Kisseleva M, Chang SC, Zou J, Feng Y, Galyov EE, Wilson M, Majerus PW. Proc Natl Acad Sci U S A: 2005;102(52):18854-18859

The identification and characterization of two phosphatidylinositol-4,5-bisphosphate 4-phosphatases Ungewickell A, Hugge C, Kisseleva M, Chang SC, Zou J, Feng Y, Galyov EE, Wilson M, Majerus PW. Proc Natl Acad Sci U S A: 2005;102(52):18854-18859

Progression of primary pneumonic plague: A mouse model of infection, pathology, and bacterial transcriptional activity Lathem WW, Crosby SD, Miller VL, Goldman WE. Proc Natl Acad Sci U S A: 2005;102(49):17786-17791

Progression of primary pneumonic plague: A mouse model of infection, pathology, and bacterial transcriptional activity Lathem WW, Crosby SD, Miller VL, Goldman WE. Proc Natl Acad Sci U S A: 2005;102(49):17786-17791

Crystallization of AcpA, a respiratory burst-inhibiting acid phosphatase from Francisella tularensis Felts RL, Reilly TJ, Tanner JJ. Biochim Biophys Acta: 2005;1752(1):107-110

Crystallization of AcpA, a respiratory burst-inhibiting acid phosphatase from Francisella tularensis Felts RL, Reilly TJ, Tanner JJ. Biochim Biophys Acta: 2005;1752(1):107-110

Catalysis of protein folding by chaperones in pathogenic bacteria Bann JG, Pinkner JS, Frieden C, Hultgren SJ. Proc Natl Acad Sci U S A: 2004:101(50):17389-17393

Catalysis of protein folding by chaperones in pathogenic bacteria Bann JG, Pinkner JS, Frieden C, Hultgren SJ. Proc Natl Acad Sci U S A: 2004:101(50):17389-17393

Burkholderia

The identification and characterization of two phosphatidylinositol-4,5-bisphosphate 4-phosphatases Ungewickell A, Hugge C, Kisseleva M, Chang SC, Zou J, Feng Y, Galyov EE, Wilson M, Majerus PW. Proc Natl Acad Sci U S A: 2005;102(52):18854-18859

Chemokines

Complement

Smallpox inhibitor of complement enzymes (SPICE): dissecting functional sites and abrogating activity Liszewski MK, Leung MK, Hauhart R, Fang CJ, Bertram P, Atkinson JP. J Immunol. 2009 Sep 1;183(5):3150-9. Epub 2009 Aug 10

Complement protein c1q inhibits antibody-dependent enhancement of flavivirus infection in an IgG subclass-specific manner Mehlhop E, Ansarah-Sobrinho C, Johnson S, Engle M, Fremont DH, Pierson TC, Diamond MS. Cell Host Microbe: 2007;2(6):417-26

West Nile virus nonstructural protein NS1 inhibits complement activation by binding the regulatory protein factor H Chung KM, Liszewski MK, Nybakken G, Davis AE, Townsend RR, Fremont DH, Atkinson JP, Diamond MS. Proc Natl Acad Sci U S A: 2006;103(50):19111-19116

Virulence differences between monkeypox virus isolates from West Africa and the Congo basin Chen N, Li G, Liszewski MK, Atkinson JP, Jahrling PB, Feng Z, Schriewer J, Buck C, Wang C, Lefkowitz EJ, Esposito JJ, Harms T, Damon IK, Roper RL, Upton C, Buller RM. Virology: 2005;340:46-63

Complement activation is required for induction of a protective antibody response against West Nile virus infection Mehlhop E, Whitby K, Oliphant T, Marri A, Engle M, Diamond MS . J Virol: 2005;79(12):7466-7477

Crimean Congo Hemorhagic Fever

Ovarian Tumor Domain-Containing Viral Proteases Evade Ubiquitin- and 1SG15-Dependent Innate Immune Responses Natalia Frias-Taheli, Nadia V Giannakopoulos, Marjolein Kikkert, Shannon L Taylor, Anne Bridgen, Jason Paragas, Juergen A Richt, Raymond R Rowland, Connie S Schmaljohn, Deborah J Lenschow, Eric J Snijder, Adolfo Garcia-Sastre and Herber Whiting Virgin IV. Cell Host & Microbe: 2007;2:404-416

Dengue

Molecular mechanisms of antibody-mediated neutralisation of flavivirus Pierson TC, Diamond MS. Expert Rev Mol Med: 2008 May 12;10:e12

Complement protein c1q inhibits antibody-dependent enhancement of flavivirus infection in an IgG subclass-specific manner Mehlhop E, Ansarah-Sobrinho C, Johnson S, Engle M, Fremont DH, Pierson TC, Diamond MS. Cell Host Microbe: 2007;2(6):417-26

Secreted NS1 of Dengue Virus Attaches to the Surface of Cells via Interactions with Heparan Sulfate and Chondroitin Sulfate E Avirutnan P, Zhang L, Punyadee N, Manuyakom A, Puttikhunt C, Kasinrerk W, Malasit P, Atkinson P, Diamond MS. PloS Pathog: 2007;3(11):1798-1812

Type- and Sub-Complex-Specific Neutralizing Antibodies Against Domain III of Dengue Virus Type-2 Envelope Protein Recognize Adjacent Epitopes Sukupolvi-Petty S, Austin SK, Purtha WE, Oliphant T, Nybakken GE, Schlesinger JJ, Roehrig JT, Gromowski GD, Barrett AD, Fremont DH, Diamond MS. J Virol: 2007;81(23):12816-12826

Diagnostics

Airborne virus capture and inactivation by an electrostatic particle collector Kettleson EM, Ramaswami B, Hogan CJ Jr, Lee MH, Statyukha GA, Biswas P, Angenent LT. Environ Sci Technol. 2009 Aug 1;43(15):5940-6

Production and characterization of monoclonal antibodies against the nucleocapsid protein of SARS-CoV Fang Y, Pekosz A, Haynes L, Nelson EA, Rowland RR. Adv Exp Med Biol: 2006;581:153-6

Ectromelia

Using biomarkers to stage disease progression in a lethal mousepox model treated with CMX001 Parker S, Schriewer J, Oberle C, Robertson A, Lanier R, Painter G, Buller RM. Antivir Ther: 2008;13(7):863-73

Primary naive and interleukin-2-activated natural killer cells do not support efficient ectromelia virus replication Parker AK, Yokoyama WM, Corbett JA, Chen N, Buller RM. J Gen Virol: 2008 Mar;89(Pt 3):751-9

Induction of natural killer cell responses by ectromelia virus controls infection Parker AK, Parker S, Yokoyama WM, Corbett JA, Buller RM. J Virol: 2007;81(8):4070-4079

Encephalitis

CXCR4 antagonism increases T cell trafficking in the central nervous system and improves survival from West Nile virus encephalitis McCandless EE, Zhang B, Diamond MS, Klein RS. Proc Natl Acad Sci U S A: 2008 Aug 12;105(32):11270-5

Entamoeba

Escherichia

Rationally designed small compounds inhibit pilus biogenesis in uropathogenic bacteria Pinkner JS, Emaut H, Buelens F, Miller e, Aberg V, Pemberton N, Hedenstrom M, Larsson A, Seed P, Waksman G,
Hultgren SJ, Almqvist F. Proc Natl Acad Sci U S A: 2006;103(47):17897-17902

Francisella

Photoaffinity antigens for human gammadelta T cells Sarikonda G, Wang H, Puan KJ, Liu XH, Lee HK, Song Y, Distefano MD, Oldfield E, Prestwich GD, Morita CT. J Immunol: 2008 Dec 1;181(11):7738-50

Preferential recognition of a microbial metabolite by human Vgamma2Vdelta2 T Cells Puan KJ, Jin C, Wang H, Sarikonda G, Raker AM, Lee HK, Samuelson MI, Marker-Hermann E, Pasa-Tolic L, Nieves E, Giner JL, Kuzuyama T, Morita CT. Int Immunol: 2007;19(5):657-673

Structural studies of Vgamma2Vdelta2 T cell phosphoantigens Zhang Y, Song Y, Yin F, Broderick E, Siegel K, Goddard A, Nieves E, Pasa-tolic L, Tanaka Y, Wang H, Morita CT, Oldfield E. Chem Biol: 2006;13(9):985-992

Crystallization of a newly discovered histidine acid phosphatase from Francisella tularensis Felts RL, Reilly TJ, Calcutt MJ, Tanner JJ. Acta Crystallograph Sect F Struct Biol Cryst Commun: 2006;62:32-35

Crystallization of AcpA, a respiratory burst-inhibiting acid phosphatase from Francisella tularensis Felts RL, Reilly TJ, Tanner JJ. Biochim Biophys Acta: 2005;1752(1):107-110

Haemophilus

Structure of Recombinant Haemophilus Influenzae e (P4) Acid Phosphatase Reveals a New Member of the Haloacid Dehalogenase Superfamily Richard L Felts, Zhonghui Ou, Thomas J Reilly, and John J Tanner. Biochemistry: 2007;46(39):11110-11119

Crystallization of recombinant Haemophilus influenzae e (P4) acid phosphatase Ou Z, Felts RL, Reilly TJ, Nix JC, Tanner JJ. Acta Crystallograph Sect F Struct Biol Cryst Commun: 2006;62:464-466

Hantavirus

The Hantavirus Glycoprotein G1 Tail Contains Dual CCHC-type Classical Zinc Fingers Estrada DF, Boudreaux DM, Zhong D, St Jeor SC, De Guzman RN. J Biol Chem: 2009 Mar 27;284(13):8654-60

Herpesvirus

Epstein-Barr virus inhibits Kaposi's sarcoma-associated herpesvirus lytic replication in primary effusion lymphomas Xu D, Coleman T, Zhang J, Fagot A, Kotalik C, Zhao L, Trivedi P, Jones C, Zhang L. J Virol: 2007;81(11):6068-6078

IFN-stimulated gene 15 functions as a critical antiviral molecule against influenza, herpes, and Sindbis viruses Lenschow DJ, Lai C, Frias-Staheli N, Giannakopoulos NV, Lutz A, Wolff T, Osiak A, Levine B, Schmidt RE, Garcia-Sastre A, Leib DA, Pekosz A, Knobeloch KP, Horak I, Virgin HW 4th. Proc Natl Acad Sci U S A: 2007;104(4):1371-1376

PKR-dependent autophagic degradation of herpes simplex virus type I Talloczy Z, Virgin HW 4th, Levine B. Autophagy: 2006;2(1):24-29

Immunology

Smallpox inhibitor of complement enzymes (SPICE): dissecting functional sites and abrogating activity Liszewski MK, Leung MK, Hauhart R, Fang CJ, Bertram P, Atkinson JP. J Immunol. 2009 Sep 1;183(5):3150-9. Epub 2009 Aug 10

Macrophage colony-stimulating factor induces the proliferation and survival of macrophages via a pathway involving DAP12 and beta-catenin Otero K, Turnbull IR, Poliani PL, Vermi W, Cerutti E, Aoshi T, Tassi I, Takai T, Stanley SL, Miller M, Shaw AS, Colonna M. Nat Immunol: 2009 Jul;10(7):734-43

Phenotypic and functional alterations of Vgamma2Vdelta2 T cell subsets in patients with active nasopharyngeal carcinoma Puan KJ, Low JS, Tan TW, Wee JT, Tan EH, Fong KW, Chua ET, Jin C, Giner JL, Morita CT, Goh CH, Hui KM. Cancer Immunol Immunother: 2009 Jul;58(7):1095-107

Autophagy genes in immunity Virgin HW, Levine B. Nat Immunol: 2009 May;10(5):461-70

Autophagy genes in immunity Virgin HW, Levine B. Nat Immunol: 2009 May;10(5):461-70

Autophagy genes in immunity Virgin HW, Levine B. Nat Immunol: 2009 May;10(5):461-70

A therapeutic antibody against west nile virus neutralizes infection by blocking fusion within endosomes Thompson BS, Moesker B, Smit JM, Wilschut J, Diamond MS, Fremont DH. PLoS Pathog: 2009 May;5(5):e1000453

A common role for Atg16L1, Atg5 and Atg7 in small intestinal Paneth cells and Crohn disease Cadwell K, Patel KK, Komatsu M, Virgin HW 4th, Stappenbeck TS. Autophagy: 2009 Feb;5(2):250-2

A common role for Atg16L1, Atg5 and Atg7 in small intestinal Paneth cells and Crohn disease Cadwell K, Patel KK, Komatsu M, Virgin HW 4th, Stappenbeck TS. Autophagy: 2009 Feb;5(2):250-2

The host immunologic response to West Nile encephalitis virus Diamond MS, Mehlhop E, Oliphant T, Samuel MA. Front Biosci: 2009 Jan 1;14:3024-34

Photoaffinity antigens for human gammadelta T cells Sarikonda G, Wang H, Puan KJ, Liu XH, Lee HK, Song Y, Distefano MD, Oldfield E, Prestwich GD, Morita CT. J Immunol: 2008 Dec 1;181(11):7738-50

Photoaffinity antigens for human gammadelta T cells Sarikonda G, Wang H, Puan KJ, Liu XH, Lee HK, Song Y, Distefano MD, Oldfield E, Prestwich GD, Morita CT. J Immunol: 2008 Dec 1;181(11):7738-50

Batf3 deficiency reveals a critical role for CD8alpha+ dendritic cells in cytotoxic T cell immunity Hildner K, Edelson BT, Purtha WE, Diamond M, Matsushita H, Kohyama M, Calderon B, Schraml BU, Unanue ER, Diamond MS, Schreiber RD, Murphy TL, Murphy KM. Science: 2008 Nov 14;322(5904):1097-100

Batf3 deficiency reveals a critical role for CD8alpha+ dendritic cells in cytotoxic T cell immunity Hildner K, Edelson BT, Purtha WE, Diamond M, Matsushita H, Kohyama M, Calderon B, Schraml BU, Unanue ER, Diamond MS, Schreiber RD, Murphy TL, Murphy KM. Science: 2008 Nov 14;322(5904):1097-100

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells Cadwell K, Liu JY, Brown SL, Miyoshi H, Loh J, Lennerz JK, Kishi C, Kc W, Carrero JA, Hunt S, Stone CD, Brunt EM, Xavier RJ, Sleckman BP, Li E, Mizushima N, Stappenbeck TS, Virgin HW 4th. Nature: 2008 Nov 13;456(7219):259-63

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells Cadwell K, Liu JY, Brown SL, Miyoshi H, Loh J, Lennerz JK, Kishi C, Kc W, Carrero JA, Hunt S, Stone CD, Brunt EM, Xavier RJ, Sleckman BP, Li E, Mizushima N, Stappenbeck TS, Virgin HW 4th. Nature: 2008 Nov 13;456(7219):259-63

Early B-cell activation after West Nile virus infection requires alpha/beta interferon but not antigen receptor signaling Purtha WE, Chachu KA, Virgin HW 4th, Diamond MS. J Virol: 2008 Nov;82(22):10964-74

The structural immunology of antibody protection against West Nile virus Diamond MS, Pierson TC, Fremont DH. Immunol Rev: 2008 Oct;225(1):212-25

The structural immunology of antibody protection against West Nile virus Diamond MS, Pierson TC, Fremont DH. Immunol Rev: 2008 Oct;225:212-25

Smallpox inhibitor of complement enzymes (SPICE): regulation of complement activation on cells and mechanism of its cellular attachment Liszewski MK, Bertram P, Leung MK, Hauhart R, Zhang L, Atkinson JP. J Immunol: 2008 Sep 15;181(6):4199-207

CXCR4 antagonism increases T cell trafficking in the central nervous system and improves survival from West Nile virus encephalitis McCandless EE, Zhang B, Diamond MS, Klein RS. Proc Natl Acad Sci U S A: 2008 Aug 12;105(32):11270-5

MDA-5 recognition of a murine norovirus McCartney SA, Thackray LB, Gitlin L, Gilfillan S, Virgin Iv HW, Colonna M. PLoS Pathog: 2008 July; 4(7): e1000108

MDA-5 recognition of a murine norovirus McCartney SA, Thackray LB, Gitlin L, Gilfillan S, Virgin Iv HW, Colonna M. PLoS Pathog: 2008 July; 4(7): e1000108

The autophagy gene ATG5 plays an essential role in B lymphocyte development Miller BC, Zhao Z, Stephenson LM, Cadwell K, Pua HH, Lee HK, Mizushima NN, Iwasaki A, He YW, Swat W, Virgin HW 4th. Autophagy: 2008 May-Jun;4(3):309-14

The autophagy gene ATG5 plays an essential role in B lymphocyte development Miller BC, Zhao Z, Stephenson LM, Cadwell K, Pua HH, Lee HK, Mizushima NN, Iwasaki A, He YW, Swat W, Virgin HW 4th. Autophagy: 2008 May-Jun;4(3):309-14

Molecular mechanisms of antibody-mediated neutralisation of flavivirus Pierson TC, Diamond MS. Expert Rev Mol Med: 2008 May 12;10:e12

The relative contribution of antibody and CD8+ T cells to vaccine immunity against West Nile encephalitis virus Bimmi Shresthaa, Terry Ngb, Hsien-Jue Chub, Michelle Nolla and Michael S Diamond. Vaccine: 2008 Apr 7;26(16):2020-33

Structure of antibody-neutralized murine norovirus and unexpected Katpally U, Wobus CE, Dryden K, Virgin HW 4th, Smith TJ. J Virol: 2008 Mar;82(5):2079-88

Primary naive and interleukin-2-activated natural killer cells do not support efficient ectromelia virus replication Parker AK, Yokoyama WM, Corbett JA, Chen N, Buller RM. J Gen Virol: 2008 Mar;89(Pt 3):751-9

Combined deficiency of proapoptotic regulators Bim and Fas results in Hutcheson J, Scatizzi JC, Siddiqui AM, Haines GK 3rd, Wu T, Li QZ,
Davis LS, Mohan C, Perlman H. Immunity: 2008 Feb;28(2):206-17

Combined deficiency of proapoptotic regulators Bim and Fas results in Hutcheson J, Scatizzi JC, Siddiqui AM, Haines GK 3rd, Wu T, Li QZ,
Davis LS, Mohan C, Perlman H. Immunity: 2008 Feb;28(2):206-17

Binding of a neutralizing antibody to dengue virus alters the arrangement of surface glycoproteins Lok SM, Kostyuchenko V, Nybakken GE, Holdaway HA, Battisti AJ, Sukupolvi-Petty S, Sedlak D, Fremont DH, Chipman PR, Roehrig JT, Diamond MS, Kuhn RJ, Rossmann MG. Nat Struct Mol Biol: 2008 Mar;15(3):312-7

Binding of a neutralizing antibody to dengue virus alters the arrangement of surface glycoproteins Lok SM, Kostyuchenko V, Nybakken GE, Holdaway HA, Battisti AJ, Sukupolvi-Petty S, Sedlak D, Fremont DH, Chipman PR, Roehrig JT, Diamond MS, Kuhn RJ, Rossmann MG. Nat Struct Mol Biol: 2008 Mar;15(3):312-7

Human major histocompatibility complex (MHC) class I molecules with Truscott SM, Wang X, Lybarger L, Biddison WE, McBerry C, Martinko
JM, Connolly JM, Linette GP, Fremont DH, Hansen TH, Carreno BM. J Biol Chem: 2008 Mar 21;283(12):7480-90

Human MHC class I molecules with disulfide traps secure disease-related antigenic peptides and exclude competitor peptides Steven M Truscott, Xiaoli Wang, Lonnie Lybarger, William E Biddison, Cortez McBerry, John M Martinko, Janet M Connolly, Gerald P Linette, Daved H Fremont, Ted H Hansen and Beatriz M Carreno. Journal of Biological Chemistry: 2008 Mar 21;283(12):7480-90

The molecular basis of antibody protection against West Nile virus Mehlhop E, Diamond MS. Curr Top Microbiol Immunol: 2008;317:125-53

Ovarian Tumor Domain-Containing Viral Proteases Evade Ubiquitin- and 1SG15-Dependent Innate Immune Responses Natalia Frias-Taheli, Nadia V Giannakopoulos, Marjolein Kikkert, Shannon L Taylor, Anne Bridgen, Jason Paragas, Juergen A Richt, Raymond R Rowland, Connie S Schmaljohn, Deborah J Lenschow, Eric J Snijder, Adolfo Garcia-Sastre and Herber Whiting Virgin IV. Cell Host & Microbe: 2007;2:404-416

Complement protein c1q inhibits antibody-dependent enhancement of flavivirus infection in an IgG subclass-specific manner Mehlhop E, Ansarah-Sobrinho C, Johnson S, Engle M, Fremont DH, Pierson TC, Diamond MS. Cell Host Microbe: 2007;2(6):417-26

Cowpox Virus Exploits the Endoplasmic Reticulum Retention Pathway to Inhibit MHC Class I Transport to the Cell Surface Byun M, Wang X, Pak M, Hansen TH, Yokoyama WM. Cell Host Microbe: 2007 Nov 15;2(5):306-315

Type- and Sub-Complex-Specific Neutralizing Antibodies Against Domain III of Dengue Virus Type-2 Envelope Protein Recognize Adjacent Epitopes Sukupolvi-Petty S, Austin SK, Purtha WE, Oliphant T, Nybakken GE, Schlesinger JJ, Roehrig JT, Gromowski GD, Barrett AD, Fremont DH, Diamond MS. J Virol: 2007;81(23):12816-12826

Induction of Epitope-Specific Neutralizing Antibodies against West Nile virus Oliphant T, Nybakken GE, Austin SK, Xu Q, Bramson J, Loeb M, Throsby M, Fremont DH, Pierson TC, Diamond MS. J Virol: 2007;81(21):11828-11839

Structural Engineering of pMHC Reagents for T Cell Vaccines and Diagnostics Mitaksov V, Truscott SM, Lybarger L, Connolly JM, Hansen TH, Fremont DH. Chem Biol: 2007;14(8):909-922

Structural Engineering of pMHC Reagents for T Cell Vaccines and Diagnostics Mitaksov V, Truscott SM, Lybarger L, Connolly JM, Hansen TH, Fremont DH. Chem Biol: 2007;14(8):909-922

Antibody recognition of cell surface-associated NS1 triggers Fc-y receptor mediated phagocytosis and clearance of WNV infected cells Kyung Min Chung, Bruce S Thompson, Daved H Fremont, and Michael S Diamond. J Virol: 2007;81(17):9551-9555

Zoonotic orthopoxviruses encode a high-affinity antagonist of NKG2D Jessica A Campbell, David S Trossman, Wayne M Yokoyama, and Leonidas N Carayannopoulos. J Exp Med: 2007;204(6):1311-1317

Antigen-specific cytotoxic T lymphocytes protect against lethal West Nile virus encephalitis Purtha WE, Myers N, Mitaksov V, Sitati E, Connolly J, Fremont DH, Hansen TH, Diamond MS. Eur J Immunol : 2007;37:1845-1854

Antigen-specific cytotoxic T lymphocytes protect against lethal West Nile virus encephalitis Purtha WE, Myers N, Mitaksov V, Sitati E, Connolly J, Fremont DH, Hansen TH, Diamond MS. Eur J Immunol : 2007;37:1845-1854

Epstein-Barr virus inhibits Kaposi's sarcoma-associated herpesvirus lytic replication in primary effusion lymphomas Xu D, Coleman T, Zhang J, Fagot A, Kotalik C, Zhao L, Trivedi P, Jones C, Zhang L. J Virol: 2007;81(11):6068-6078

The molecular basis of antibody-mediated neutralization of West Nile virus Theodore Oliphant, Michael S Diamond. Expert Opin Biol Ther: 2007;7(6):885-892

Defining limits of humanized neutralizing monoclonal antibody treatment for West Nile virus neurological infection in a hamster model Morrey JD, Siddharthan V, Olsen AL, Wang H, Julaner JG, Hall JO, Li H, Nordstrom JL, Koenig S, Johnson S, Diamond MS. Antimicrob Agents Chemother: 2007;51(7):2396-2402

Disulfide bond engineering to trap peptides in the MHC class I binding groove Truscott SM, Lybarger L, Martinko JM, Mitaksov VE, Kranz DM, Connolly JM, Fremont DH, Hansen TH. J Immunol: 2007;178(10):6280-6289

Preferential recognition of a microbial metabolite by human Vgamma2Vdelta2 T Cells Puan KJ, Jin C, Wang H, Sarikonda G, Raker AM, Lee HK, Samuelson MI, Marker-Hermann E, Pasa-Tolic L, Nieves E, Giner JL, Kuzuyama T, Morita CT. Int Immunol: 2007;19(5):657-673

Preferential recognition of a microbial metabolite by human Vgamma2Vdelta2 T Cells Puan KJ, Jin C, Wang H, Sarikonda G, Raker AM, Lee HK, Samuelson MI, Marker-Hermann E, Pasa-Tolic L, Nieves E, Giner JL, Kuzuyama T, Morita CT. Int Immunol: 2007;19(5):657-673

Murine norovirus 1 infection is associated with histopathological changes in immunocompetent hosts but clinical disease is prevented by STAT1-dependent interferon responses Mumphrey SM, Changotra H, Moore TN, Heimann-Nichols ER, Wobus CE, Reilly MJ, Moghadamfalahi M, Shukla D, Karst SM. J Virol: 2007;81(7):3251-3263

Induction of natural killer cell responses by ectromelia virus controls infection Parker AK, Parker S, Yokoyama WM, Corbett JA, Buller RM. J Virol: 2007;81(8):4070-4079

Murine norovirus 1 infection is associated with histopathological changes in immunocompetent hosts but clinical disease is prevented by STAT1-dependent interferon responses Mumphrey SM, Changotra H, Moore TN, Heimann-Nichols ER, Wobus CE, Reilly MJ, Moghadamfalahi M, Shukla D, Karst SM. J Virol: 2007;81(7):3251-3263

Induction of natural killer cell responses by ectromelia virus controls infection Parker AK, Parker S, Yokoyama WM, Corbett JA, Buller RM. J Virol: 2007;81(8):4070-4079

IFN-stimulated gene 15 functions as a critical antiviral molecule against influenza, herpes, and Sindbis viruses Lenschow DJ, Lai C, Frias-Staheli N, Giannakopoulos NV, Lutz A, Wolff T, Osiak A, Levine B, Schmidt RE, Garcia-Sastre A, Leib DA, Pekosz A, Knobeloch KP, Horak I, Virgin HW 4th. Proc Natl Acad Sci U S A: 2007;104(4):1371-1376

IFN-stimulated gene 15 functions as a critical antiviral molecule against influenza, herpes, and Sindbis viruses Lenschow DJ, Lai C, Frias-Staheli N, Giannakopoulos NV, Lutz A, Wolff T, Osiak A, Levine B, Schmidt RE, Garcia-Sastre A, Leib DA, Pekosz A, Knobeloch KP, Horak I, Virgin HW 4th. Proc Natl Acad Sci U S A: 2007;104(4):1371-1376

West Nile virus nonstructural protein NS1 inhibits complement activation by binding the regulatory protein factor H Chung KM, Liszewski MK, Nybakken G, Davis AE, Townsend RR, Fremont DH, Atkinson JP, Diamond MS. Proc Natl Acad Sci U S A: 2006;103(50):19111-19116

Structural studies of Vgamma2Vdelta2 T cell phosphoantigens Zhang Y, Song Y, Yin F, Broderick E, Siegel K, Goddard A, Nieves E, Pasa-tolic L, Tanaka Y, Wang H, Morita CT, Oldfield E. Chem Biol: 2006;13(9):985-992

Structural studies of Vgamma2Vdelta2 T cell phosphoantigens Zhang Y, Song Y, Yin F, Broderick E, Siegel K, Goddard A, Nieves E, Pasa-tolic L, Tanaka Y, Wang H, Morita CT, Oldfield E. Chem Biol: 2006;13(9):985-992

PKR-dependent autophagic degradation of herpes simplex virus type I Talloczy Z, Virgin HW 4th, Levine B. Autophagy: 2006;2(1):24-29

Antibody recognition and neutralization determinants on domains I and II of West Nile Virus envelope protein Oliphant T, Nybakken GE, Engle M, Xu Q, Nelson CA, Sukupolvi-Petty S, Marri A, Lachmi BE, Olshevsky U, Fremont DH, Pierson TC, Diamond MS. J Virol: 2006;80(24):12149-12159

Antibody recognition and neutralization determinants on domains I and II of West Nile Virus envelope protein Oliphant T, Nybakken GE, Engle M, Xu Q, Nelson CA, Sukupolvi-Petty S, Marri A, Lachmi BE, Olshevsky U, Fremont DH, Pierson TC, Diamond MS. J Virol: 2006;80(24):12149-12159

PKR-dependent autophagic degradation of herpes simplex virus type I Talloczy Z, Virgin HW 4th, Levine B. Autophagy: 2006;2(1):24-29

Structure and regulatory profile of the monkeypox inhibitor of complement: comparison to homologs in vaccinia and variola and evidence for dimer formation Liszewski MK, Leung MK, Hauhart R, Buller RM, Bertram P, Wang X, Rosengard AM, Kotwal GJ, Atkinson JP. J Immunol: 2006;176(6):3725-3734

Structure and regulatory profile of the monkeypox inhibitor of complement: comparison to homologs in vaccinia and variola and evidence for dimer formation Liszewski MK, Leung MK, Hauhart R, Buller RM, Bertram P, Wang X, Rosengard AM, Kotwal GJ, Atkinson JP. J Immunol: 2006;176(6):3725-3734

Antibodies against West Nile Virus nonstructural protein NS1 prevent lethal infection through Fc gamma receptor-dependent and -independent mechanisms Chung KM, Nybakken GE, Thompson BS, Engle MJ, Marri A, Fremont DH, Diamond MS. J Virol: 2006;80(3):1340-1351

Antibodies against West Nile Virus nonstructural protein NS1 prevent lethal infection through Fc gamma receptor-dependent and -independent mechanisms Chung KM, Nybakken GE, Thompson BS, Engle MJ, Marri A, Fremont DH, Diamond MS. J Virol: 2006;80(3):1340-1351

Identification of interferon-stimulated gene 15 as an antiviral molecule during Sindbis virus infection in vivo Lenschow DJ, Giannakopoulos NV, Gunn LJ, Johnston C, O'Guin AK, Schmidt RE, Levine B, Virgin HW 4th. J Virol: 2005;79(22):13974-13983

Identification of interferon-stimulated gene 15 as an antiviral molecule during Sindbis virus infection in vivo Lenschow DJ, Giannakopoulos NV, Gunn LJ, Johnston C, O'Guin AK, Schmidt RE, Levine B, Virgin HW 4th. J Virol: 2005;79(22):13974-13983

Proteomic identification of proteins conjugated to ISG15 in mouse and human cells Giannakopoulos NV, Luo JK, Papov V, Zou W, Lenschow DJ, Jacobs BS, Borden EC, Li J, Virgin HW, Zhang DE. Biochem Biophys Res Commun: 2005;336(2):496-506

Proteomic identification of proteins conjugated to ISG15 in mouse and human cells Giannakopoulos NV, Luo JK, Papov V, Zou W, Lenschow DJ, Jacobs BS, Borden EC, Li J, Virgin HW, Zhang DE. Biochem Biophys Res Commun: 2005;336(2):496-506

Structural basis of West Nile Virus neutralization by a therapeutic antibody Nybakken GE, Oliphant T, Johnson S, Burke S, Diamond MS, Fremont DH. Nature: 2005;437:764-769

Virulence differences between monkeypox virus isolates from West Africa and the Congo basin Chen N, Li G, Liszewski MK, Atkinson JP, Jahrling PB, Feng Z, Schriewer J, Buck C, Wang C, Lefkowitz EJ, Esposito JJ, Harms T, Damon IK, Roper RL, Upton C, Buller RM. Virology: 2005;340:46-63

Complement activation is required for induction of a protective antibody response against West Nile virus infection Mehlhop E, Whitby K, Oliphant T, Marri A, Engle M, Diamond MS . J Virol: 2005;79(12):7466-7477

Complement activation is required for induction of a protective antibody response against West Nile virus infection Mehlhop E, Whitby K, Oliphant T, Marri A, Engle M, Diamond MS . J Virol: 2005;79(12):7466-7477

Development of a humanized monoclonal antibody with therapeutic potential against West Nile virus Oliphant T, Engle M, Nybakken GE, Doane C, Johnson S, Huang L, Gorlatov S, Mehlhop E, Marri A, Chung KM, Ebel GD, Kramer LD, Fremont DH, Diamond MS. Nat Med: 2005;11(5):522-530

Adhesion of human T cells to antigen-presenting cells through SIRP{beta}2-CD47 interaction costimulates T cell proliferation Piccio L, Vermi W, Boles KS, Fuchs A, Strader CA, Facchetti F, Cella M, Colonna M. Blood: 2005;105(6):2421-2427

Adhesion of human T cells to antigen-presenting cells through SIRP{beta}2-CD47 interaction costimulates T cell proliferation Piccio L, Vermi W, Boles KS, Fuchs A, Strader CA, Facchetti F, Cella M, Colonna M. Blood: 2005;105(6):2421-2427

Role of CD8+ T cells in control of West Nile virus infection Shrestha B, Diamond MS. J Virol: 2004;78(15):8312-8321

Interferon

Autophagy genes in immunity Virgin HW, Levine B. Nat Immunol: 2009 May;10(5):461-70

A common role for Atg16L1, Atg5 and Atg7 in small intestinal Paneth cells and Crohn disease Cadwell K, Patel KK, Komatsu M, Virgin HW 4th, Stappenbeck TS. Autophagy: 2009 Feb;5(2):250-2

Early B-cell activation after West Nile virus infection requires alpha/beta interferon but not antigen receptor signaling Purtha WE, Chachu KA, Virgin HW 4th, Diamond MS. J Virol: 2008 Nov;82(22):10964-74

Ovarian Tumor Domain-Containing Viral Proteases Evade Ubiquitin- and 1SG15-Dependent Innate Immune Responses Natalia Frias-Taheli, Nadia V Giannakopoulos, Marjolein Kikkert, Shannon L Taylor, Anne Bridgen, Jason Paragas, Juergen A Richt, Raymond R Rowland, Connie S Schmaljohn, Deborah J Lenschow, Eric J Snijder, Adolfo Garcia-Sastre and Herber Whiting Virgin IV. Cell Host & Microbe: 2007;2:404-416

Murine norovirus 1 infection is associated with histopathological changes in immunocompetent hosts but clinical disease is prevented by STAT1-dependent interferon responses Mumphrey SM, Changotra H, Moore TN, Heimann-Nichols ER, Wobus CE, Reilly MJ, Moghadamfalahi M, Shukla D, Karst SM. J Virol: 2007;81(7):3251-3263

IFN-stimulated gene 15 functions as a critical antiviral molecule against influenza, herpes, and Sindbis viruses Lenschow DJ, Lai C, Frias-Staheli N, Giannakopoulos NV, Lutz A, Wolff T, Osiak A, Levine B, Schmidt RE, Garcia-Sastre A, Leib DA, Pekosz A, Knobeloch KP, Horak I, Virgin HW 4th. Proc Natl Acad Sci U S A: 2007;104(4):1371-1376

Identification of interferon-stimulated gene 15 as an antiviral molecule during Sindbis virus infection in vivo Lenschow DJ, Giannakopoulos NV, Gunn LJ, Johnston C, O'Guin AK, Schmidt RE, Levine B, Virgin HW 4th. J Virol: 2005;79(22):13974-13983

Proteomic identification of proteins conjugated to ISG15 in mouse and human cells Giannakopoulos NV, Luo JK, Papov V, Zou W, Lenschow DJ, Jacobs BS, Borden EC, Li J, Virgin HW, Zhang DE. Biochem Biophys Res Commun: 2005;336(2):496-506

Midway Virus

Nyamanini and midway viruses define a novel taxon of RNA viruses in the order Mononegavirales Mihindukulasuriya KA, Nguyen NL, Wu G, Huang HV, da Rosa AP, Popov VL, Tesh RB, Wang D. J Virol: 2009 May;83(10):5109-16

Monkeypox

Therapeutic and prophylactic drugs to treat orthopoxvirus infections Parker S, Handley L, Buller RM. Future Virol. 2008 Nov;3(6):595-612

Experimental infection of an African dormouse (Graphiurus kelleni) with monkeypox virus Schultz DA, Sagartz JE, Huso DL, Buller RM. Virology: 2008 Oct 31

Zoonotic orthopoxviruses encode a high-affinity antagonist of NKG2D Jessica A Campbell, David S Trossman, Wayne M Yokoyama, and Leonidas N Carayannopoulos. J Exp Med: 2007;204(6):1311-1317

Structure and regulatory profile of the monkeypox inhibitor of complement: comparison to homologs in vaccinia and variola and evidence for dimer formation Liszewski MK, Leung MK, Hauhart R, Buller RM, Bertram P, Wang X, Rosengard AM, Kotwal GJ, Atkinson JP. J Immunol: 2006;176(6):3725-3734

Virulence differences between monkeypox virus isolates from West Africa and the Congo basin Chen N, Li G, Liszewski MK, Atkinson JP, Jahrling PB, Feng Z, Schriewer J, Buck C, Wang C, Lefkowitz EJ, Esposito JJ, Harms T, Damon IK, Roper RL, Upton C, Buller RM. Virology: 2005;340:46-63

NK Cells

Primary naive and interleukin-2-activated natural killer cells do not support efficient ectromelia virus replication Parker AK, Yokoyama WM, Corbett JA, Chen N, Buller RM. J Gen Virol: 2008 Mar;89(Pt 3):751-9

Cowpox Virus Exploits the Endoplasmic Reticulum Retention Pathway to Inhibit MHC Class I Transport to the Cell Surface Byun M, Wang X, Pak M, Hansen TH, Yokoyama WM. Cell Host Microbe: 2007 Nov 15;2(5):306-315

Zoonotic orthopoxviruses encode a high-affinity antagonist of NKG2D Jessica A Campbell, David S Trossman, Wayne M Yokoyama, and Leonidas N Carayannopoulos. J Exp Med: 2007;204(6):1311-1317

Induction of natural killer cell responses by ectromelia virus controls infection Parker AK, Parker S, Yokoyama WM, Corbett JA, Buller RM. J Virol: 2007;81(8):4070-4079

norovirus

MDA-5 recognition of a murine norovirus McCartney SA, Thackray LB, Gitlin L, Gilfillan S, Virgin Iv HW, Colonna M. PLoS Pathog: 2008 July; 4(7): e1000108

Structure of antibody-neutralized murine norovirus and unexpected Katpally U, Wobus CE, Dryden K, Virgin HW 4th, Smith TJ. J Virol: 2008 Mar;82(5):2079-88

Murine noroviruses comprising a single genogroup exhibit biological diversity despite limited sequence divergence Thackray, LB, Wobus CE, Chachu KA, Liu B, Alegre ER, Henderson KS, Kelley ST, Virgin HW. J Virol: 2007;8(19):10460-10473

Murine norovirus 1 infection is associated with histopathological changes in immunocompetent hosts but clinical disease is prevented by STAT1-dependent interferon responses Mumphrey SM, Changotra H, Moore TN, Heimann-Nichols ER, Wobus CE, Reilly MJ, Moghadamfalahi M, Shukla D, Karst SM. J Virol: 2007;81(7):3251-3263

Molecular characterization of three novel murine noroviruses Hsu CC, Riley LK, Livingston RS. Virus Genes: 2007;34(2):147-155

Persistent infection with and serologic cross-reactivity of three novel murine noroviruses Hsu CC, Riley LK, Wills HM, Livingston RS. Comp Med: 2006;56(4):247-251

Murine norovirus: a model system to study norovirus biology and pathogenesis Wobus CE, Thackray LB, Virgin HW 4th. J Virol: 2006;80(11):5104-5112

Nyamanini virus

Nyamanini and midway viruses define a novel taxon of RNA viruses in the order Mononegavirales Mihindukulasuriya KA, Nguyen NL, Wu G, Huang HV, da Rosa AP, Popov VL, Tesh RB, Wang D. J Virol: 2009 May;83(10):5109-16

Pathogen Discovery

Quaranfil, Johnston Atoll and Lake Chad viruses are novel members of the family Orthomyxoviridae Presti RM, Zhao G, Beatty WL, Mihindukulasuriya KA, Travassos da Rosa AP, Popov VL, Tesh RB, Virgin HW, Wang D. J Virol. 2009 Sep 2

Identification of a novel astrovirus (Astrovirus VA1) associated with an outbreak of acute gastroenteritis Finkbeiner SR, Li Y, Ruone S, Conrardy C, Gregoricus N, Toney D, Virgin HW, Anderson LJ, Vinjé J, Wang D, Tong S. J Virol. 2009 Aug 12

Klassevirus 1, a previously undescribed member of the family Picornaviridae, is globally widespread Holtz LR, Finkbeiner SR, Zhao G, Kirkwood CD, Girones R, Pipas JM, Wang D. Virol J: 2009 Jun 24;6:86

Nyamanini and midway viruses define a novel taxon of RNA viruses in the order Mononegavirales Mihindukulasuriya KA, Nguyen NL, Wu G, Huang HV, da Rosa AP, Popov VL, Tesh RB, Wang D. J Virol: 2009 May;83(10):5109-16

Detection of newly described astrovirus MLB1 in stool samples from children Finkbeiner SR, Le BM, Holtz LR, Storch GA, Wang D. Emerg Infect Dis

MDA-5 recognition of a murine norovirus McCartney SA, Thackray LB, Gitlin L, Gilfillan S, Virgin Iv HW, Colonna M. PLoS Pathog: 2008 July; 4(7): e1000108

Clinical and Epidemiologic Characterization of WU Polyomavirus Infection, St. Louis, Missouri Binh-Minh Le, Lee M Demertzis, Guang Wu, Robert J Tibbets, Richard Buller, Max Q Arens, anne M Gaynor, Gregory A Storch, and David Wang. Emerging Infectious Diseases: 2007;13(12):1936-1938

Clinical and Epidemiologic Characterization of WU Polyomavirus Infection, St. Louis, Missouri Binh-Minh Le, Lee M Demertzis, Guang Wu, Robert J Tibbets, Richard Buller, Max Q Arens, anne M Gaynor, Gregory A Storch, and David Wang. Emerging Infectious Diseases: 2007;13(12):1936-1938

Identification and characterization of small molecules that inhibit intracellular toxin transport Jose B Saenz, Teresa A Doggett, David B Haslam. Infect Immun: 2007;75(9):4552-4561

Identification of a novel polyomavirus from patients with respiratory tract infections Gaynor Anne M, Nissen Michael D, Whiley David M, Mackay Ian M, Lambert Stephen B, Wu Guang, Brennan Daniel C, Storch Gregory A, Sloots Theo P, Wang David. PLoS Pathog: 2007;3(5):0595-0604

Identification of a novel polyomavirus from patients with respiratory tract infections Gaynor Anne M, Nissen Michael D, Whiley David M, Mackay Ian M, Lambert Stephen B, Wu Guang, Brennan Daniel C, Storch Gregory A, Sloots Theo P, Wang David. PLoS Pathog: 2007;3(5):0595-0604

Molecular characterization of three novel murine noroviruses Hsu CC, Riley LK, Livingston RS. Virus Genes: 2007;34(2):147-155

Molecular characterization of three novel murine noroviruses Hsu CC, Riley LK, Livingston RS. Virus Genes: 2007;34(2):147-155

Tickborne arbovirus surveillance in market livestock, Nairobi, Kenya Sang R, Onyango C, Gachoya J, Mabinda E, Konongoi S, Ofula V, Dunster L, Okoth F, Coldren R, Tesh R, da Rossa AT, Finkbeiner S, Wang D, Crabtree M, Miller B. Emerg Infect Dis: 2006 Jul;12(7):1074-80

Tickborne arbovirus surveillance in market livestock, Nairobi, Kenya Sang R, Onyango C, Gachoya J, Mabinda E, Konongoi S, Ofula V, Dunster L, Okoth F, Coldren R, Tesh R, da Rossa AT, Finkbeiner S, Wang D, Crabtree M, Miller B. Emerg Infect Dis: 2006 Jul;12(7):1074-80

Sampling methodologies and dosage assessment techniques for submicrometre and ultrafine virus aerosol particles Hogan CJ Jr, Kettleson EM, Lee MH, Ramaswami B, Angenent LT, Biswas P. J Appl Microbiol: 2005;99:1422-1434

Ricin

Golgicide A reveals essential roles for GBF1 in Golgi assembly and function José B Sáenz, William J , Jae Won Chang, Jinmei Li, Badry Bursulaya, Nathanael S Gray & David B Haslam. Nature Chemical Biology 5, 157 - 165 (: 2009)

SARS-CoV

An immunosuppressed Syrian golden hamster model for SARS-CoV infection Schaecher SR, Stabenow J, Oberle C, Schriewer J, Buller RM, Sagartz JE, Pekosz A. Virology: 2008 Aug 27

Coronavirus Replication Does Not Require the Autophagy Gene ATG5 Zhao Z, Thackray LB, Miller BC, Lynn TM, Becker MM, Ward E, Mizushima NN, Denison MR, Virgin HW 4th. Autophagy: 2007;3(6):581-585

Production and characterization of monoclonal antibodies against the nucleocapsid protein of SARS-CoV Fang Y, Pekosz A, Haynes L, Nelson EA, Rowland RR. Adv Exp Med Biol: 2006;581:153-6

Structure, expression and intracellular localization of the SARS-CoV accessory proteins 7a and 7b Pekosz A, Schaecher SR, Diamond MS, Fremont DH, Sims AC, Baric RS. Adv Exp Med Biol: 2006;581:115-120

Shigella

Golgicide A reveals essential roles for GBF1 in Golgi assembly and function José B Sáenz, William J , Jae Won Chang, Jinmei Li, Badry Bursulaya, Nathanael S Gray & David B Haslam. Nature Chemical Biology 5, 157 - 165 (: 2009)

Sindbis

Identification of interferon-stimulated gene 15 as an antiviral molecule during Sindbis virus infection in vivo Lenschow DJ, Giannakopoulos NV, Gunn LJ, Johnston C, O'Guin AK, Schmidt RE, Levine B, Virgin HW 4th. J Virol: 2005;79(22):13974-13983

Smallpox

Smallpox inhibitor of complement enzymes (SPICE): dissecting functional sites and abrogating activity Liszewski MK, Leung MK, Hauhart R, Fang CJ, Bertram P, Atkinson JP. J Immunol. 2009 Sep 1;183(5):3150-9. Epub 2009 Aug 10

Therapeutic and prophylactic drugs to treat orthopoxvirus infections Parker S, Handley L, Buller RM. Future Virol. 2008 Nov;3(6):595-612

Smallpox inhibitor of complement enzymes (SPICE): regulation of complement activation on cells and mechanism of its cellular attachment Liszewski MK, Bertram P, Leung MK, Hauhart R, Zhang L, Atkinson JP. J Immunol: 2008 Sep 15;181(6):4199-207

Structure and regulatory profile of the monkeypox inhibitor of complement: comparison to homologs in vaccinia and variola and evidence for dimer formation Liszewski MK, Leung MK, Hauhart R, Buller RM, Bertram P, Wang X, Rosengard AM, Kotwal GJ, Atkinson JP. J Immunol: 2006;176(6):3725-3734

T Cells

Photoaffinity antigens for human gammadelta T cells Sarikonda G, Wang H, Puan KJ, Liu XH, Lee HK, Song Y, Distefano MD, Oldfield E, Prestwich GD, Morita CT. J Immunol: 2008 Dec 1;181(11):7738-50

Batf3 deficiency reveals a critical role for CD8alpha+ dendritic cells in cytotoxic T cell immunity Hildner K, Edelson BT, Purtha WE, Diamond M, Matsushita H, Kohyama M, Calderon B, Schraml BU, Unanue ER, Diamond MS, Schreiber RD, Murphy TL, Murphy KM. Science: 2008 Nov 14;322(5904):1097-100

The relative contribution of antibody and CD8+ T cells to vaccine immunity against West Nile encephalitis virus Bimmi Shresthaa, Terry Ngb, Hsien-Jue Chub, Michelle Nolla and Michael S Diamond. Vaccine: 2008 Apr 7;26(16):2020-33

Human major histocompatibility complex (MHC) class I molecules with Truscott SM, Wang X, Lybarger L, Biddison WE, McBerry C, Martinko
JM, Connolly JM, Linette GP, Fremont DH, Hansen TH, Carreno BM. J Biol Chem: 2008 Mar 21;283(12):7480-90

Structural Engineering of pMHC Reagents for T Cell Vaccines and Diagnostics Mitaksov V, Truscott SM, Lybarger L, Connolly JM, Hansen TH, Fremont DH. Chem Biol: 2007;14(8):909-922

Antigen-specific cytotoxic T lymphocytes protect against lethal West Nile virus encephalitis Purtha WE, Myers N, Mitaksov V, Sitati E, Connolly J, Fremont DH, Hansen TH, Diamond MS. Eur J Immunol : 2007;37:1845-1854

Preferential recognition of a microbial metabolite by human Vgamma2Vdelta2 T Cells Puan KJ, Jin C, Wang H, Sarikonda G, Raker AM, Lee HK, Samuelson MI, Marker-Hermann E, Pasa-Tolic L, Nieves E, Giner JL, Kuzuyama T, Morita CT. Int Immunol: 2007;19(5):657-673

Adhesion of human T cells to antigen-presenting cells through SIRP{beta}2-CD47 interaction costimulates T cell proliferation Piccio L, Vermi W, Boles KS, Fuchs A, Strader CA, Facchetti F, Cella M, Colonna M. Blood: 2005;105(6):2421-2427

Role of CD8+ T cells in control of West Nile virus infection Shrestha B, Diamond MS. J Virol: 2004;78(15):8312-8321

Theilovirus

Differential susceptibility of SD and CD rats to a novel rat theilovirus Drake MT, Riley LK, Livingston RS. Comp Med: 2008 Oct;58(5):458-64

Therapeutics

Human monoclonal antibodies against West Nile virus induced by natural infection neutralize at a postattachment step Vogt MR, Moesker B, Goudsmit J, Jongeneelen M, Austin SK, Oliphant T, Nelson S, Pierson TC, Wilschut J, Throsby M, Diamond MS. J Virol: 2009 Jul;83(13):6494-507

A therapeutic antibody against west nile virus neutralizes infection by blocking fusion within endosomes Thompson BS, Moesker B, Smit JM, Wilschut J, Diamond MS, Fremont DH. PLoS Pathog: 2009 May;5(5):e1000453

Phosphonosulfonates are potent, selective inhibitors of dehydrosqualene synthase and staphyloxanthin biosynthesis in Staphylococcus aureus Song Y, Lin FY, Yin F, Hensler M, Rodrígues Poveda CA, Mukkamala D, Cao R, Wang H, Morita CT, González Pacanowska D, Nizet V, Oldfield E. J Med Chem. 2009 Feb 26;52(4):976-88

Using biomarkers to stage disease progression in a lethal mousepox model treated with CMX001 Parker S, Schriewer J, Oberle C, Robertson A, Lanier R, Painter G, Buller RM. Antivir Ther: 2008;13(7):863-73

The structural immunology of antibody protection against West Nile virus Diamond MS, Pierson TC, Fremont DH. Immunol Rev: 2008 Oct;225:212-25

Smallpox inhibitor of complement enzymes (SPICE): regulation of complement activation on cells and mechanism of its cellular attachment Liszewski MK, Bertram P, Leung MK, Hauhart R, Zhang L, Atkinson JP. J Immunol: 2008 Sep 15;181(6):4199-207

Molecular mechanisms of antibody-mediated neutralisation of flavivirus Pierson TC, Diamond MS. Expert Rev Mol Med: 2008 May 12;10:e12

Structure of antibody-neutralized murine norovirus and unexpected Katpally U, Wobus CE, Dryden K, Virgin HW 4th, Smith TJ. J Virol: 2008 Mar;82(5):2079-88

Binding of a neutralizing antibody to dengue virus alters the arrangement of surface glycoproteins Lok SM, Kostyuchenko V, Nybakken GE, Holdaway HA, Battisti AJ, Sukupolvi-Petty S, Sedlak D, Fremont DH, Chipman PR, Roehrig JT, Diamond MS, Kuhn RJ, Rossmann MG. Nat Struct Mol Biol: 2008 Mar;15(3):312-7

Type- and Sub-Complex-Specific Neutralizing Antibodies Against Domain III of Dengue Virus Type-2 Envelope Protein Recognize Adjacent Epitopes Sukupolvi-Petty S, Austin SK, Purtha WE, Oliphant T, Nybakken GE, Schlesinger JJ, Roehrig JT, Gromowski GD, Barrett AD, Fremont DH, Diamond MS. J Virol: 2007;81(23):12816-12826

Induction of Epitope-Specific Neutralizing Antibodies against West Nile virus Oliphant T, Nybakken GE, Austin SK, Xu Q, Bramson J, Loeb M, Throsby M, Fremont DH, Pierson TC, Diamond MS. J Virol: 2007;81(21):11828-11839

Antibody recognition of cell surface-associated NS1 triggers Fc-y receptor mediated phagocytosis and clearance of WNV infected cells Kyung Min Chung, Bruce S Thompson, Daved H Fremont, and Michael S Diamond. J Virol: 2007;81(17):9551-9555

The molecular basis of antibody-mediated neutralization of West Nile virus Theodore Oliphant, Michael S Diamond. Expert Opin Biol Ther: 2007;7(6):885-892

Induction of natural killer cell responses by ectromelia virus controls infection Parker AK, Parker S, Yokoyama WM, Corbett JA, Buller RM. J Virol: 2007;81(8):4070-4079

IFN-stimulated gene 15 functions as a critical antiviral molecule against influenza, herpes, and Sindbis viruses Lenschow DJ, Lai C, Frias-Staheli N, Giannakopoulos NV, Lutz A, Wolff T, Osiak A, Levine B, Schmidt RE, Garcia-Sastre A, Leib DA, Pekosz A, Knobeloch KP, Horak I, Virgin HW 4th. Proc Natl Acad Sci U S A: 2007;104(4):1371-1376

Rationally designed small compounds inhibit pilus biogenesis in uropathogenic bacteria Pinkner JS, Emaut H, Buelens F, Miller e, Aberg V, Pemberton N, Hedenstrom M, Larsson A, Seed P, Waksman G,
Hultgren SJ, Almqvist F. Proc Natl Acad Sci U S A: 2006;103(47):17897-17902

Production and characterization of monoclonal antibodies against the nucleocapsid protein of SARS-CoV Fang Y, Pekosz A, Haynes L, Nelson EA, Rowland RR. Adv Exp Med Biol: 2006;581:153-6

Antibodies against West Nile Virus nonstructural protein NS1 prevent lethal infection through Fc gamma receptor-dependent and -independent mechanisms Chung KM, Nybakken GE, Thompson BS, Engle MJ, Marri A, Fremont DH, Diamond MS. J Virol: 2006;80(3):1340-1351

Structural basis of West Nile Virus neutralization by a therapeutic antibody Nybakken GE, Oliphant T, Johnson S, Burke S, Diamond MS, Fremont DH. Nature: 2005;437:764-769

Development of a humanized monoclonal antibody with therapeutic potential against West Nile virus Oliphant T, Engle M, Nybakken GE, Doane C, Johnson S, Huang L, Gorlatov S, Mehlhop E, Marri A, Chung KM, Ebel GD, Kramer LD, Fremont DH, Diamond MS. Nat Med: 2005;11(5):522-530

TNF

Toxins

Golgicide A reveals essential roles for GBF1 in Golgi assembly and function José B Sáenz, William J , Jae Won Chang, Jinmei Li, Badry Bursulaya, Nathanael S Gray & David B Haslam. Nature Chemical Biology 5, 157 - 165 (: 2009)

Effect of 2-Fluorohistidine Labeling of the Anthrax Protective Antigen on Stability, Pore Formation, and Translocation Wimalasena DS, Cramer JC, Janowiak BE, Juris SJ, Melnyk RA, Anderson DE, Kirk KL, Collier RJ, Bann JG. Biochemistry: 2007 Dec 25;46(51):14928-36

Pathophysiological manifestations in mice exposed to anthrax lethal toxin Culley NC, Pinson DM, Chakrabarty A, Mayo MS, Levine SM. Infect Immun: 2005;73(10):7006-7010

Virology

Nyamanini and midway viruses define a novel taxon of RNA viruses in the order Mononegavirales Mihindukulasuriya KA, Nguyen NL, Wu G, Huang HV, da Rosa AP, Popov VL, Tesh RB, Wang D. J Virol: 2009 May;83(10):5109-16

Smallpox inhibitor of complement enzymes (SPICE): regulation of complement activation on cells and mechanism of its cellular attachment Liszewski MK, Bertram P, Leung MK, Hauhart R, Zhang L, Atkinson JP. J Immunol: 2008 Sep 15;181(6):4199-207

Defining the Levels of Secreted Non-Structural Protein NS1 After West Nile Virus Infection in Cell Culture and Mice Kyung Min Chung and Michael S Diamond. Journal of Medical Virology: 2008;80:547-556

The molecular basis of antibody protection against West Nile virus Mehlhop E, Diamond MS. Curr Top Microbiol Immunol: 2008;317:125-53

Cowpox Virus Exploits the Endoplasmic Reticulum Retention Pathway to Inhibit MHC Class I Transport to the Cell Surface Byun M, Wang X, Pak M, Hansen TH, Yokoyama WM. Cell Host Microbe: 2007 Nov 15;2(5):306-315

Secreted NS1 of Dengue Virus Attaches to the Surface of Cells via Interactions with Heparan Sulfate and Chondroitin Sulfate E Avirutnan P, Zhang L, Punyadee N, Manuyakom A, Puttikhunt C, Kasinrerk W, Malasit P, Atkinson P, Diamond MS. PloS Pathog: 2007;3(11):1798-1812

Murine noroviruses comprising a single genogroup exhibit biological diversity despite limited sequence divergence Thackray, LB, Wobus CE, Chachu KA, Liu B, Alegre ER, Henderson KS, Kelley ST, Virgin HW. J Virol: 2007;8(19):10460-10473

Coronavirus Replication Does Not Require the Autophagy Gene ATG5 Zhao Z, Thackray LB, Miller BC, Lynn TM, Becker MM, Ward E, Mizushima NN, Denison MR, Virgin HW 4th. Autophagy: 2007;3(6):581-585

Epstein-Barr virus inhibits Kaposi's sarcoma-associated herpesvirus lytic replication in primary effusion lymphomas Xu D, Coleman T, Zhang J, Fagot A, Kotalik C, Zhao L, Trivedi P, Jones C, Zhang L. J Virol: 2007;81(11):6068-6078

West Nile virus nonstructural protein NS1 inhibits complement activation by binding the regulatory protein factor H Chung KM, Liszewski MK, Nybakken G, Davis AE, Townsend RR, Fremont DH, Atkinson JP, Diamond MS. Proc Natl Acad Sci U S A: 2006;103(50):19111-19116

Persistent infection with and serologic cross-reactivity of three novel murine noroviruses Hsu CC, Riley LK, Wills HM, Livingston RS. Comp Med: 2006;56(4):247-251

Production and characterization of monoclonal antibodies against the nucleocapsid protein of SARS-CoV Fang Y, Pekosz A, Haynes L, Nelson EA, Rowland RR. Adv Exp Med Biol: 2006;581:153-6

Crystal structure of the West Nile virus envelope glycoprotein Nybakken GE, Nelson CA, Chen BR, Diamond MS, Fremont DH. J Virol: 2006;80(23):11467-11474

Antibody recognition and neutralization determinants on domains I and II of West Nile Virus envelope protein Oliphant T, Nybakken GE, Engle M, Xu Q, Nelson CA, Sukupolvi-Petty S, Marri A, Lachmi BE, Olshevsky U, Fremont DH, Pierson TC, Diamond MS. J Virol: 2006;80(24):12149-12159

Structure and regulatory profile of the monkeypox inhibitor of complement: comparison to homologs in vaccinia and variola and evidence for dimer formation Liszewski MK, Leung MK, Hauhart R, Buller RM, Bertram P, Wang X, Rosengard AM, Kotwal GJ, Atkinson JP. J Immunol: 2006;176(6):3725-3734